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The ONCO-ADJUNCT™ Pathway System brings a thoughtful approach to cellular imbalances using Liquid Protein Scaffold™ (LPS™) technology and terpene enrichment, which support absorption of bioactive polyphenols.

This product should only be used in consultation with your medical provider.

We encourage you to learn everything you can about the specific pathways affected in your individual case… and to work closely with your doctor and/or a licensed medical or health care provider to choose the optimal pathway combination to address your own cellular imbalances.

This product is not intended to replace treatments recommended to you by your doctor and/or a licensed medical or health care provider.

Pathway 4™

Promotes Immune Function & Cell Cycles*

ONCO-ADJUNCT™ Pathway 4™ is a nutritional supplement that combines Beta Glucans with three LPS™ bioactive polyphenols using brown rice as the scaffold.

LPS™ technology delivers molecular polyphenols such as Fisetin, EGCG, and Resveratrol to your body by using protein as the carrier. Without LPS™ technology they are not assimilated because they don’t dissolve.

  1. LPS™ Brown Rice-Fisetin Complex – May support Sirtuin, NRF2, and NFkB pathways.*
  2. LPS™ Brown Rice-EGCG Complex – May support cellular health by influencing optimal autophagy.*
  3. LPS™ Brown Rice-Resveratrol Complex – May support Sirtuin, NRF2, and NFkB pathways as well.*
  4. Beta Glucans – May support optimal function of immune system.* Our source for Beta-glucan, called PureMune™, activates all three parts of the immune system, not just the Dectin 1. The activation of the Complement Immune System is critically important for overall immune health.*

Taken together with Pathways 1™, 2™/2-Ferro™, and 3™, these substances help to modulate the healthy function of your cellular pathways to promote cellular health.*

Dosing Instructions: 2 capsules twice daily

More About the P4 Ingredients

Research shows that these substances provide various types of health support.


  • Stimulates the Sirtuin (SIRT1) pathway, enhancing cellular autophagy and promoting overall cellular health*
  • Activates the NRF2 pathway, boosting cellular antioxidant response and protecting against oxidative stress*
  • Modulates the NF-κB pathway, contributing to a balanced cellular response*


  • Modulates the AMPK pathway, supporting cellular energy balance and metabolic health*
  • Affects the NF-κB pathway, promoting a balanced cellular response*
  • Influences the MAPK/ERK pathway, impacting cell cycle regulation and cellular health*


  • Stimulates the Sirtuin (SIRT1) pathway, promoting cellular autophagy and overall cellular health*
  • Activates the AMPK pathway, enhancing cellular energy balance and metabolic function*
  • Regulates the NF-κB pathway, for a balanced cellular response*

Beta Glucan:

  • Engages with immune cell receptors, such as Dectin-1, to support optimal immune cell function and immune response at a cellular level*
  • Activates the complement system, strengthening immune cell communication and coordination*
  • Stimulates the production of cytokines, modulating cellular immune response and promoting overall immune health*


This product should only be used under medical supervision.

We advise you to consult with your healthcare practitioners regarding any questions or concerns about using these products, as well as their appropriate dosing for you.

*Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration, and are not intended to diagnose, treat, cure, or prevent any disease or health condition.


The Onco-Adjunct family of products is generally well-tolerated. We advise you to consult with your healthcare practitioner regarding any questions or concerns about using these products, as well as the appropriate dosing for your needs.

We have a blood thinner warning on Pathway 2™, as it has a blood thinning effect. If you are taking blood thinners, consult with your physician before using.

Additionally, you should skip taking Pathway 2™ (or P2-Ferro™) on the day before, day of, or day after undergoing chemotherapy, unless guided otherwise by your physician, as it may diminish the effectiveness of chemo cytotoxic interventions.

These products should only be used under medical supervision. Do not use without consulting your doctor if you are taking any blood thinners.

We advise you to consult with your healthcare practitioners regarding any questions or concerns about using these products, and their appropriate dosing.

Do not take this product on the day before, day of, or day after a chemotherapy treatment, as it may diminish the effectiveness of chemo cytotoxic interventions.

The following interactions with curcumin have been discussed in the literature:

  1. Chemo therapeutic suppression was potentially found with curcumin and camptothecin, mechlorethamine, and doxorubicin. Somasundaram S, Edmund NA, Moore DT, Small GW, Shi YY, Orlowski RZ. Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res. 2002;62(13):3868-3875. (PubMed)


  2. Curcumin affects the FXa node in the thrombin pathway. Any anti-coagulant therapy that acts directly on thrombin should be avoided (Hirudin, Argatroban, Bivalirudin, Dabigatran). Any Indirect or direct FXa inhibitors should be discussed with your doctor.

We are not licensed medical practitioners and therefore cannot dispense medical advice. We can refer you to product information provided on our website… or read a bottle label to you. However, we cannot give you any medical or dosing advice specific to your situation.

This is a very individual decision that should be made in collaboration with your licensed medical provider.

Your physician will have his or her testing protocols, so you should work with them in these measurements.

We include recommended dosing on each label. But we strongly recommend you work with and follow the advice of your physician.

The difference is found in the technology we utilize to get the polyphenols into your system. Most polyphenols have long been defined by their inability to absorb into the human body.

We solved that problem with Liquid Protein Scaffold™ (LPS™) technology.

A group of researchers from Oklahoma Medical Research Foundation and the University of Oklahoma were exploring ways to take certain plant extracts that were very poorly absorbed in the gut and make them ultra-bioavailable.

The result was a molecular curcumin that was taken in capsule form. Tests were performed showing never-before-seen exponential levels in the bloodstream, with rapid, transformative results. We now apply LPS™ Technology to a variety of other botanicals so they can deliver maximum cellular support to humans and animals.

Some people do experience an initial drowsiness with Pathway 1™ due to the presence of cannabinoids, though the THC levels fall below the 0.3% limit. We therefore recommend a half dose for the first three days, taken at bedtime.

You should not operate a motor vehicle or other equipment until you have experience of how your body interacts with it. Drowsiness usually diminishes rapidly as your body adjusts.

Due to the THC content in Pathway 1™, you will test positive if subjected to a drug test.

We now offer a THC-free version of Pathway 1™, which provides you with an alternate option if you don’t want the drowsiness effect or are concerned about the potential for a drug test.

Dietary supplements are regulated by the FDA with regards to manufacture and label claims. However, supplements are never approved in the way that pharmaceutical drugs are.

All our products, including our Pathway™ products, are manufactured in strict accordance with Good Manufacturing Practice (GMP) protocols in our own pharma manufacturing facility. Our facility has been inspected by the FDA.

Many of our ingredients are sourced from India (where most of the world’s curcumin is grown) and the Middle East, with some support ingredients sourced from the United States and other parts of Asia. We source from companies that work with local farmers who do NOT use pesticides or GMOs.

When ingredients hit our loading dock, they are put into a “quarantine” status until we can test for whether the ingredient is actually that which is on the label. We run numerous purity tests throughout the entire production process. In addition, there are additional tests and standard operating procedures that are part of our GMP certification.

All our products are made at our FDA-registered, GMP-certified facility in central Oklahoma City, Oklahoma, in the U.S.A.

Pathway 2™ and Pathway 2-Ferro™ utilize two different protein scaffolds. Pathway 2-Ferro™ uses shellfish-free chondroitin as the scaffold for curcumin and quercetin, with synergistic frankincense. It is favored by those who are trying to reduce cysteine in their diet. Pathway 2™ uses brown rice as a scaffold.

Natural cell clearing relates to the natural death of an old or damaged cell. Curcumin and quercetin may help your body clear those cells to make room for newer cells by stimulating the p53 pathway.*

Pathway 1™ contains three ingredients that support different cellular pathways in our cells.* For example, hemp extract may support the PPAR-gamma pathway – an epigenetic pathway responsible for the differentiation and division of cells.* Frankincense may support optimal cell proliferation by influencing the caspase pathway.*

Absolutely. We welcome interactions with medical professionals and are willing to speak with your healthcare provider via Zoom of phone appointment. Please set up an appointment by calling 405-694-4175 X7001.

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