If you read last week’s article on senescence you may be wondering what you can do to train old, useless cells to die and make room for newer more youthful cells. (If you missed it, you can read it here.)
Senolytic agents are compounds that are shown to boost wellness and extend lifespan in experimental models. Senescent cells are a major driver of age-related disease and dysfunction. Scientists believe they actively accelerate the aging process.
These compounds work by training those old cells to die so they can make room for newer ones. Research shows that senolytic compounds slow or possibly even reverse the aging process.
Fisetin, a plant-based flavonoid, is one of the most powerful natural senolytics ever discovered.
If you read last week’s article on senescence you may be wondering what you can do to train old, useless cells to die and make room for newer more youthful cells. (If you missed it, you can read it here.)
Senolytic agents are compounds that are shown to boost wellness and extend lifespan in experimental models. Senescent cells are a major driver of age-related disease and dysfunction. Scientists believe they actively accelerate the aging process.
These compounds work by training those old cells to die so they can make room for newer ones. Research shows that senolytic compounds slow or possibly even reverse the aging process.
Fisetin, a plant-based flavonoid, is one of the most powerful natural senolytics ever discovered.
Fisetin has become popular over the past few years due to its potential health benefits.
Fisetin is found in a number of fruits and vegetables notably, strawberries, apples, persimmons, grapes, and onions.
In addition, fisetin shows some of the same anti-aging and disease-fighting qualities of other polyphenols. Yet remarkably, fisetin is especially potent as a senolytic compound.
Fisetin, like many other polyphenols, is hard to absorb and especially difficult to get into the cells.
Similarly to the Liquid Protein Scaffolding™ used for curcumin and quercetin, fisetin made with LPS™ technology increases bioavailability and allows you to actually feel its effects. Fast! Meaning that it will have greater impact on your health and longevity.
Fisetin is a more powerful senolytic than most other compounds. It works on its own, without having to be combined with other drugs (and their potential side effects).
A study published in the journal Aging showed that fisetin removed about 70% of senescent cells, without collateral damage to healthy cells.
Another study examined 10 plant-derived compounds head-to-head. Of the 10, fisetin was the most effective in getting rid of senescent cells – in both cell cultures and in animals.
An animal study showed that when mice at the human equivalent of 75 years old were given fisetin, they lived 2.5 months longer. That’s nearly a 10% increase in lifespan.
Currently there are a number of human studies in progress.
1. Mimics Calorie Restriction
Research shows that fisetin affects every one of these pathways in mimicking the effects of calorie restriction.1
Sirtuin proteins, for example, shield cells from damage and keep them in shipshape form. However, sirtuin function decreases with age, which results in greater susceptibility to disease and rapid aging.2, 3, 4
AMPK also diminishes with age, increasing risk of obesity, diabetes, metabolic dysfunction, and more.5
Multiple preclinical studies show that fisetin boosts sirtuin function and AMPK activity.6, 7
Despite the evidence, calorie restriction is a tough sell for most people. Fisetin may help address that level of non-compliance.
In addition to extending lifespan, fisetin may also reduce the risk of common chronic diseases, such as heart disease (which remains a leading cause of death).
Heart disease involves inadequate oxygen/blood/nutrient flow, which can lead to a heart attack.
Studies in the past couple years have shown that fisetin can protect the heart from injury. And decrease damage after a heart attack.
A study published in Nature showed that fisetin protected rat heart cells that were starved for nutrients and oxygen, preventing heart cell death.1
Heart attack damage was reduced and heart function preserved when treated with fisetin.2
Fisetin taken after a heart attack can reduce the risk of subsequent A-fib, which is common and is linked with greater likelihood of stroke or heart failure.3
Two preclinical studies show fisetin to be effective in controlling even highly aggressive forms of cancer – glioblastoma and triple negative breast cancer.
Glioblastoma is one of the most invasive and rapidly growing types of cancer. Even with chemo and surgery, it’s nearly impossible to control. Fisetin significantly reduced the growth of glioblastoma cells, and caused them to die off. Compared to a chemotherapy drug called carmustine, fisetin killed cancer cells – and at lower doses.
Fisetin was also effective against triple negative breast cancer, which is highly resistant to most medical treatments.
Other studies show that fisetin helps prevent metastasis, reduce inflammation, enhance autophagy, and trigger cancer cell death.
Obesity predisposes people to greater risk of cardiovascular disease, as well as cancer, dementia, and more.
Fisetin increases AMPK activity and decreases mTOR. Therefore it helps reduce weight gain and protects against related conditions. This was true even in mice fed a high-fat diet. Not only did it prevent weight gain but also protected the heart, liver, and other organs.
Animal models of diabetes show that fisetin lowers body weight and improves glucose control and insulin sensitivity.
Better glucose control in turn helps protect against many related complications, such as kidney disease, eye disease, and neurological disorders.
Experts suggest that fasting blood glucose be kept in a range from 70 to 85 mg/dL. This is challenging for most older people to do, but fisetin may help you achieve that.
Fisetin has also been shown to protect the brain in animal models of Alzheimer’s disease, Parkinson’s disease, ALS, and more.
A 2019 clinical study found that fisetin helped in stroke treatment. The best window for successful stroke treatment is within 3 hours of the stroke. Fisetin can extend that window to 5 hours, which could boost the number of stroke patients to benefit from brain-saving therapy.
Inflammation can greatly accelerate the aging process and increase your risk for chronic disease.
Fisetin helps scavenge free radicals and prevent DNA, protein, and other cellular damage.
Fisetin turns off pathways that promote inflammation, and reduces the production of pro-inflammatory compounds.
Joe Tippens’ cancer recovery story quickly spread to 96 countries. Join us as we discuss his story on our podcast. You won’t believe the phone call he got recently from China… and the nickname assigned to his protocol over there.
From small cell lung cancer and widespread mestastesis in December of 2016 to alive and kicking in 2023, he’s lived quite the testament to the idea you can recover. And he’s helped countless others too.
Watch the video on YouTube now . Prefer audio only? Listen on Spotify now.
Disclaimer: The opinions of our guest belong to our guest, and do not necessarily constitute an endorsement by UltraBotanica, LLC. We always recommend that your medical decisions be made only after consulting with a licensed medical practitioner.
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