FREE shipping in the continental U.S. for RETAIL orders over $50.00!


Fermented Wheat Germ Extract: A Superfood for Longevity

Fermented Wheat Germ Extract: A Superfood for Longevity

Man doing sit-up exercises outdoors

I want to tell you about a little-known superfood that packs a serious punch when it comes to your health and longevity.

It’s called fermented wheat germ extract (FWGE), and it’s been quietly transforming lives behind the scenes for years.

You might even remember seeing a jar of wheat germ in the pantry of a grandparent, uncle, or aunt. Or you might be thinking, “Wheat germ? Isn’t that just some boring old health food?” But trust me, this stuff is anything but boring. 

In fact, it’s been shown to have impressive effects on everything from supporting your metabolic pathways to immune system support.

What Is Fermented Wheat Germ Extract?

Fermented wheat germ extract is a natural supplement that’s gotten attention lately for its potential health benefits.

It’s derived from the germ of the wheat kernel, which is the nutrient-rich embryo that sprouts and grows into a new wheat plant. 

But not all wheat germ extracts are created equal. The key difference lies in the fermentation process.

Top view worker holds wheat or barley in hands, in warehouse of brewery food industry. Ingredients for beer at factory

Fermented vs. Unfermented Wheat Germ

When wheat germ undergoes fermentation, it unleashes a whole host of beneficial compounds that aren’t present in the unfermented version.

The fermentation process breaks down the tough cell walls of the wheat germ, making the nutrients more bioavailable and easier for our bodies to absorb. And that’s especially true for people who may struggle with eating gluten.

Extraction Process

The production of fermented wheat germ extract is like brewing a fine wine – it takes time, expertise, and a whole lot of TLC.

First, the wheat germ is separated from the rest of the wheat kernel and carefully fermented with a special strain of baker’s yeast. This process can take anywhere from a few days to several weeks, depending on the specific method used. 

Once the fermentation is complete, the wheat germ is then extracted to concentrate the beneficial compounds. The result is a potent, bioavailable supplement.

Key Compounds in Fermented Wheat Germ Extract

One of the star players in fermented wheat germ extract is a group of compounds called benzoquinones, specifically 2-methoxy benzoquinone and 2,6-dimethoxy benzoquinone. 

Polyamines have generated much attention since the 1990s for their anti-aging benefits, their actions against chronic disease, and their proliferative effects.

Wheat germ is recognized as one of the best natural sources of polyamines, especially spermidine. 

Fermented wheat germ extract is also rich in other beneficial compounds like flavonoids and polyphenols. These plant-based powerhouses have been linked to a wide range of health benefits. 

The combination of these compounds is what makes fermented wheat germ extract such a unique and potent supplement. It’s like a superfood dream team, working together to support our health in ways that few other supplements can match.

Athletic seniors playing pickleball on court indoors

Top 7 Anti-Aging Benefits of Fermented Wheat Germ Extract

Let’s dive into the incredible anti-aging benefits of spermidine — the compound found in fermented wheat germ extract (FWGE). 

1. Promotes Autophagy

Autophagy is a major player in maintaining cellular health and slowing the aging process. It’s basically the process of “pruning” a plant — getting rid of excess less-than-functional cells that are taking up space but not providing any real value. 

By promoting autophagy, spermidine helps your cells get rid of damaged components and stay in tip-top shape [1].

2. Reduces Oxidative Stress

Oxidative stress is a big contributor to aging and age-related diseases. Fermented wheat germ extract has been shown to reduce oxidative stress, which helps protect your cells from damage, as well as delay aging [1].

3. Supports Cardiovascular Health

Evidence suggests that spermidine can help strengthen blood vessels and improve vasodilation, which can help regulate blood pressure and reduce your risk of cardiovascular conditions [1].

4. Enhances Mitochondrial Function

Mitochondria are like little powerhouses in your cells, and spermidine enhances their function. By improving mitochondrial function, spermidine can help maintain cellular energy levels and reduce the risk of age-related decline [1].

5. Boosts Immune Function

As we age, our immune systems can fall into decline. Spermidine has been found to have immune-boosting properties, which may protect against age-related immune decline and reduce the risk of infections and conditions in older adults [1].

6. Improves Cognitive Function

Studies have shown that fermented wheat germ extract can improve cognitive function and protect against age-related cognitive decline, possibly due to its ability to promote neuronal health and support overall brain health [1]. 

Spermidine may also help dissolve amyloid plaques in the brain. 

Clinical trials of adults aged 60 – 100 years found that doses of 0.9 – 3.3mg/d of fermented wheat germ extract improved memory compared to placebo. 

7. Increases Lifespan

FWGE has increased lifespan in various animal studies. Supplementing with spermidine and/or fermented wheat germ extract helps prevent age-related conditions, improves stress resistance, and ultimately extends lifespan [2]. 

In animal studies spermidine extends lifespans by 3 times in yeast, 30% in flies, 15% in worms, and 10% in old mice. 

Elderly couple dancing on summer vacation. Generate ai

Other Anti-Aging Benefits of Fermented Wheat Germ Extract

1. Supports Healthy DNA Division 

Studies have shown that the unique compounds in this supplement, particularly the benzoquinones, may help to support healthy cell growth [3]. 

Fermented wheat germ extract has also been shown to induce apoptosis (programmed cell death) in various types of cells [4]. 

2. Supports Mental Health and Cognition

The unique compounds in fermented wheat germ extract, particularly the flavonoids and polyphenols, have been shown to reduce oxidative stress in the brain.

This may help to improve mood, reduce anxiety and depression, and enhance memory and learning abilities. 

3. Boosts Immune System Function

The immunomodulatory properties of this supplement have been shown to stimulate the production and activity of immune cells [5], particularly natural killer cells and T-lymphocytes.

This can help to strengthen our body’s natural defenses against infections and more. 

4. Supports Metabolic and Cardiovascular Health

Fermented wheat germ extract may also have powerful benefits for cardiovascular and metabolic health. Its antioxidant properties are shown to reduce oxidative stress in the body [6].

By supporting healthy blood sugar levels and insulin sensitivity, and protecting against oxidative damage to our blood vessels and heart, FWGE may be a valuable tool for wellness. 

💡 Key Takeaway: 

Fermented wheat germ extract is a nutrient-rich supplement with unique compounds like benzoquinones, polyamines, flavonoids, and polyphenols. 

These antioxidants support healthy cell growth, reduce menopause symptoms, boost mental health and immunity, and help support metabolic and cardiovascular health.

How FWGE Promotes Longevity

So, we’ve seen the incredible anti-aging benefits of fermented wheat germ extract, but how exactly does it promote longevity?

Intermittent fasting and autophagy: a cell character engulfs old, discarded cellular material, undergoing a transformative process of self-renewal and rejuvenation.

Activation of Autophagy Pathways

One of the key ways FWGE effects longevity is by activating autophagy pathways. As we’ve discussed, autophagy and its removal of old cells that take up space but don’t contribute plays an essential role in maintaining cellular health and function.

By removing old and damaged cellular components, FWGE helps keep your cells young and healthy, which aids increased lifespan and health span [1].

Think of it as though your healthy cells are consuming the senescent cells as part of the process to get rid of them and create rejuvenation

Regulation of Gene Expression

FWGE has also been shown to regulate gene expression, particularly in genes related to aging and longevity. By modulating the expression of these genes, spermidine may help promote healthy aging and extend lifespan [1].

Modulation of Cellular Processes

Spermidine promotes longevity by modulating various cellular processes, like improving mitochondrial function and enhancing stress response.

These positive effects work together to protect your cells from age-related damage and keep them functioning at their best [1].

Modulates Immune System Response

The immune system plays a key role in longevity, but sometimes it needs a bit of help.

Fermented wheat germ extract stimulates the production and activity of immune cells, including natural killer (NK) cells and T-lymphocytes. These cells are like the body’s own army, seeking out and destroying “enemy” cells. 

You have more than one type of immunity. One part, your innate immune system, is with you from birth.

Another part, your acquired immunity, is immunity that learns and adapts to your environment and protects you against issues your innate immune system can’t protect you against.

Guards Your DNA

A key enzyme targeted by FWGE is ribonucleotide reductase, which is critical for DNA synthesis and repair. 

Induces Programmed Cell Death

Fermented wheat germ extract can induce apoptosis or programmed cell death. Apoptosis is a tightly regulated process that helps the body get rid of damaged or abnormal cells.

Fermented wheat germ extract has been shown to activate specific signaling pathways and genes that trigger apoptosis.  

💡 Key Takeaway: 

Fermented wheat germ extract starves cells of sugar, induces apoptosis, and boosts immune response. 

How to Incorporate Fermented Wheat Germ Extract into Your Diet

So, you’re intrigued by the potential benefits of fermented wheat germ extract and want to give it a try. But where do you start? First things first, let’s talk dosage.

Recommended Dosage

The recommended dosage of fermented wheat germ extract varies depending on the specific product and the individual’s health status. Generally, the suggested daily dose ranges from 2 to 9 grams, preferably divided into two or three smaller doses throughout the day. 

Supplement Forms

Fermented wheat germ extract is available in various supplement forms, including capsules, tablets, and powders… including a new product we will be launching in a few days called Onco-Adjunct Pathway 3+, which is an LPS™ berberine blend with FWGE. The two are an optimal combination for our enhanced Pathway 3 (now Pathway 3+) product. 

Hospital: Cheerful Doctor Gives Good News To Patient

Precautions and Drug Interactions

While fermented wheat germ extract is generally considered safe, some people may experience minor side effects such as digestive discomfort, nausea, or headaches.

It’s important to consult with a healthcare professional before taking the extract, especially if you have a pre-existing medical condition or are taking medications.

Ask your integrative physician if Pathway 3+ might be a good substitute for the original Pathway 3.


So, there you have it, folks. Fermented wheat germ extract (FWGE) is a true superfood that can help support your health and longevity in countless ways. It’s worth adding to your daily routine.

And the best part? It’s easy to incorporate into your diet. Just take 1 capsule before a light meal or 2 capsules before a heavier meal. 

So why not give our brand new fermented wheat germ extract a try? Your body and your longevity will thank you!

Table of Contents


Fermented Wheat Germ Extract: A Superfood for Longevity

YES Please! I want in!

By submitting this form you are agreeing to receive emails from Ultra Botanica. You can unsubscribe at any time.