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Curcumin’s Effects on Longevity

Curcumin’s Effects on Longevity

Healthy aging and human longevity are intricate characteristics affected by lifestyle factors such as physical exercise, diet, health habits, as well as genetic factors. Caloric restriction also plays a crucial role in healthy aging.

A Healthy Aging Nutrient  

Curcumin is a polyphenolic compound found in the spice turmeric. The beautiful, rich, yellow-gold spice has been used in Indian cooking and traditional Ayurvedic medicine for thousands of years. [1]

In the past couple decades, curcumin has gained increasing attention for its potential lifespan benefits, including its healthy aging effects… sometimes dubbed “healthspan” instead of lifespan. “Healthspan” denotes the number of years living independently while aging well.

Research shows that curcumin helps prevent processes that drive aging and chronic disorders, including cell senescence and chronic inflammation. [2,3,4]  The overall effect may be to improve healthy longevity.  

A large group of fit and active people doing exercise in nature, stretching.

We All Want to Feel Our Best!

Here are just a few of the potential healthy aging effects of curcumin to keep you feeling your best.

1. Antioxidant activity. Curcumin possesses strong antioxidant properties, which can help combat oxidative stress. Oxidative stress is a major contributor to aging and various age related diseases. By neutralizing harmful free radicals, curcumin may help protect cells and tissues from damage and slow down the aging process.  

2. Supports a healthy inflammatory response. Chronic inflammation is another driver of aging. By triggering a healthy inflammatory response, curcumin may help keep you active and living a healthy lifestyle until later in life. [9]

Antioxidant activity of curcumin was been detected to be about 10 times higher than vitamin E. [5] Curcumin is a potent antioxidant with great potential to reduce age-related cellular damage induced by the generation of reactive oxygen species (ROS). Due to the presence of phenolic groups at the chemical structure of curcumin, it shows a powerful hydrogen-donating antioxidant activity. [ 6,7,8]

3. Cellular health and longevity.  As cells age, some become  senescent. Senescence is a process which a cell ages and permanently stops dividing but does not die. These cells are dysfunctional and emit protein-degrading enzymes but refuse to die off to make room for healthy cells.   

Senescent cells also secrete inflammatory compounds that damage surrounding tissues. [10]   Curcumin has demonstrated the potential to reduce the number of senescent cells in tissues. [11,12] Curcumin also activates autophagy, the cellular “house-keeping,” to rejuvenate cells and keep them functioning optimally. [13]

4. Cognitive Support.   Nearly anyone over a certain age will tell you that keeping a sharp mind is high on their list for healthy aging. A number of studies have found that curcumin supplementation supports cognition and memory. [14]

Every strand of DNA in our body has protective end caps, called  telomeres, which help maintain the stability and function of our genetic material. As we age, these telomeres shorten. Shortened telomeres limit regeneration and stem cell function.

Telomerase is an enzyme that builds up the length of existing telomeres. Curcumin has been shown to give a boost to this anti-aging enzyme. It can enhance the expression and activity of telomerase, increasing the health and life of cells. [15,16]

5. Skin Health.  Curcumin may also benefit skin health and contribute to a more youthful appearance! It can help protect the skin from damage caused by UV radiation and environmental pollutants.

Curcumin may also enhance collagen production, improve skin elasticity, and reduce the appearance of wrinkles and age spots. [17]

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What About Absorption?

On its own, curcumin has extremely low bioavailability. Much of the curcumin you consume is never absorbed into the bloodstream, which may be why you don’t feel a difference taking it.

The UltraCür Difference  

UltraCür’s innovation solves the problem with our breakthrough, patented LPS technology. LPS, “Liquid Protein Scaffold” binds molecular bioactive plant extracts to protein or amino acid scaffolds. This allows for easy digestion and absorption into your body and cells. 

Studies with our technology show absorption in as little as 20 minutes. 70% of users felt a dramatic change within 7 days. And 50% of users felt it in less than 24 hours.

Sources

[1] Available at:  https://www.ncbi.nlm.nih.gov/books/NBK92752/ . (Accessed on July 08, 2023)

[2]  Bahrami A, Montecucco F, Carbone F, et al. Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence. Biomed Res Int. 2021;2021:8972074.

[3] Benameur T, Soleti R, Panaro MA, et al. Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain. Molecules. 2021 Aug 7;26(16).

[4] Zia A, Farkhondeh T, Pourbagher-Shahri AM, et al. The role of curcumin in aging and senescence: Molecular mechanisms. Biomed Pharmacother. 2021 Feb;134:111119.

[5] S.M. Khopde, K.I. Priyadarsini, P. Venkatesan, M. Rao. Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue, Biophys. Chem., 80 (2) (1999), pp. 85-91

[6] T. Farkhondeh, S. Samarghandian, A.M. Pourbagher-Shahri, M.Sedaghat  The impact of curcumin and its modified formulations on Alzheimer’s disease, J. Cell. Physiol., 234 (10) (2019), pp. 16953-16965

[7]  A. Amalraj, A. Pius, S. Gopi, S. Gopi Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives–A review J. Tradit. Complement. Med., 7 (2) (2017), pp. 205-233

[8] B. Kocaadam, N. Sanlier Curcumin, an active component of turmeric (Curcuma longa), and its effects on health Crit. Rev. Food Sci. Nutr., 57 (13) (2017), pp. 2889-2895

[9] Bahrami A, Montecucco F, Carbone F, et al. Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence. Biomed Res Int. 2021;2021:8972074.

[10] Ohtani N. The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis? Inflamm Regen. 2022 Apr 2;42(1):11.

[11] Cherif H, Bisson DG, Jarzem P, et al. Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro. J Clin Med. 2019 Mar 29;8(4).

[12] MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28.

[13] Rainey NE, Moustapha A, Petit PX. Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and Apoptosis. Oxid Med Cell Longev. 2020;2020:3656419.

[14] Seddon N, D’Cunha NM, Mellor DD, et al. Effects of Curcumin on Cognitive Function—A Systematic Review of Randomized Controlled Trials. Exploratory Research and Hypothesis in Medicine. 2019 03/19;4(1):1-11.

[15] Taka T, Changtam C, Thaichana P, et al. Curcuminoid derivatives enhance telomerase activity in an in vitro TRAP assay. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5242-6.

[16] Xiao Z, Zhang A, Lin J, et al. Telomerase: a target for therapeutic effects of curcumin and a curcumin derivative in Abeta1-42 insult in vitro. PLoS One. 2014;9(7):e101251.

[17] S. Tavakol, S. Zare, E. Hoveizi, B. Tavakol, S.M. Rezayat. The impact of the particle size of curcumin nanocarriers and the ethanol on beta_1-integrin overexpression in fibroblasts: a regenerative pharmaceutical approach in skin repair and anti-aging formulations Daru., 27 (1) (2019), pp. 159-168  

Episode 67

When Doctors Run the Wrong Tests, Then Accuse You of Being Psychotic

When Dr. Windham was first diagnosed with fibromyalgia, you won’t believe where they marched her off to immediately. 

Yet certain tests point to the truth about that and other misunderstood diseases! 

If a doctor has ever implied that you’re crazy because they personally don’t believe a disease exists, you completely owe it to yourself to listen to this segment… where Dr. Windham tells of her personal experience in this exact situation.   

Learn what to do, and address this and the tests most doctors never even run.

Watch the video on YouTube now. Prefer audio only?

Listen on Spotify now.

THIS ENTRY WAS POSTED BY ADAM PAYNE

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Curcumin’s Effects on Longevity

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